Cardiac Electrophysiology

Vascular Development and Disease

Phenotype-Chemotype-Genotype Predictions

Our Research

Our research is centered around the human genetics of cardiac and vascular disease, cardiovascular developmental biology, and drug discovery. By using zebrafish as a model organism, we’re able to scale clinically relevant, complex physiology to expedite drug discovery and offer a window into disease pathology.

Dr. Calum MacRae is a cardiologist, geneticist and developmental biologist who trained in Edinburgh, London and Boston. He is the Vice Chair for Scientific Innovation at the Department of Medicine at Brigham and Women’s Hospital and Professor of Medicine at Harvard Medical School. In addition, Dr. MacRae is a Principal Faculty Member at the Harvard Stem Cell Institute, and an Associate Member at the Broad Institute.



Changing how coronary heart disease is detected, prevented, and treated.

Lab News

Check out the latest cardiovascular development and drug discovery projects from our lab.