Originating from Japan, Masahiro obtained his MD/Ph.D. from Chiba University. His thesis aimed to better understand how heart failure develops at a single cell level. He was a postdoctoral researcher at The University of Tokyo and joined the MacRae Lab as a research fellow in 2019. Masahiro is interested in understanding the molecular mechanisms of heart development and the pathophysiology of cardiovascular disease to identify the potential molecular target for therapeutic intervention. To fully understand the dynamic profile of cells carrying a pathogenic mutation, Masa uses scRNA-seq at different developmental stages to identify the earliest transcriptional changes occurring during heart failure and to follow the different trajectories of wild-type and mutant cells to better understand their behavior over time.