Manu Beerens

Having completed my PhD studying the development of the lymphatic vasculature at the KULeuven, Belgium, I joined the MacRae lab in 2014. My primary research focuses on the vascular and cardiac implementations of perturbations in Notch signaling by altering the expression of de novo identified genetic interactors of this pathway. The ultimate goal of these studies is to unravel the complex genetic and cellular machinery that underlies many of the pathological defects observed in patients, using zebrafish larvae as a readout model. I am also interested in the signals that instruct endothelial cells to switch cell fate in a variety of biological settings, including cardiac valve formation and hematopoietic stem cell specification. Finally, I use an automated screening approach to identify phenotype-drug associations in a variety of disease settings.